San Francisco 49ers wide receiver Steve Johnson (13) celebrates with teammates after catching a 12-yard touchdown against the Philadelphia Eagles during the third quarter of his team's come-from-behind 26-21 victory.

The Philadelphia Eagles got a taste of their own medicine.

After three weeks of uplifting rallies to victory, the Eagles lost for the first time, blowing a lead in a 26-21 defeat to the 49ers. San Francisco’s Frank Gore caught a career-best 55-yard touchdown and ran for 119 yards in his first 100-yard game this year.

Philadelphia led 21-10 in the second quarter, even though it got no points from its high-powered offense. And the 49ers (2-2) delivered a late goal-line stand as they avoided their first three-game losing streak under fourth-year coach Jim Harbaugh, containing the league’s top passer in Nick Foles. He threw two incomplete passes from the 1 in the waning moments.

“We had the ball enough,” running back LeSean McCoy said. “We didn’t do anything with it.”

Darren Sproles had a career-best 82-yard punt return for a touchdown, Malcolm Jenkins ran an interception 53 yards for a score for the Eagles (3-1), and Brad Smith recovered a blocked punt for a TD.

But the Niners shut down Philly’s attack, which had scored 34, 30 and 37 points, rallying from at least 10 points down in winning all of those games.

“It is very satisfying,” said San Francisco cornerback Perrish Cox, who had a late interception. “We gave up plenty of yards these last two weeks on just penalties. A few third-and-longs, some hands-to-the-face, a couple illegal touchings downfield. Those are tough and tiring at the same time. To go out and hold a great offense like they have, with the tempo they play, to a shutout, it feels good.”

Colin Kaepernick threw the short pass that Gore turned into his long TD and also threw a touchdown pass to Stevie Johnson. Phil Dawson kicked four field goals for San Francisco.

Cowboys 38, Saints 17At Arlington, Texas, Tony Romo threw three touchdowns passes, two to Terrance Williams, and DeMarco Murray ran for a pair of scores in another 100-yard game. Murray is the only Cowboys running back aside from Emmitt Smith to rush for 100 yards in each of the first four games of a season.

Packers 38, Bears 17At Chicago, the Packers joined the Bears as the only franchises with 700 regular-season victories.Aaron Rodgers threw for 302 yards and four touchdowns as the Packers (2-2) scored on their first six possessions. They racked up 358 yards after being held to 223, their lowest total since 2008, a week earlier in a 19-7 loss at Detroit.

Ravens 38, Panthers 10At Baltimore, Steve Smith punished his former team with seven catches for 139 yards and two touchdowns. Smith spent 13 seasons with Carolina before he was released in a cost-cutting move during the offseason. The 35-year-old receiver showed the Panthers he can still make the big play, scoring twice in the second quarter to help put Baltimore (3-1) in front 21-7 at halftime.

Chargers 33, Jaguars 14At San Diego, Philip Rivers threw for 377 yards and three touchdowns, two to Eddie Royal.Royal had scoring catches of 47 and 43 yards, his second straight two-touchdown game. Royal had five catches for 105 yards, Keenan Allen had 10 for 135, both career highs, and Malcom Floyd had a 24-yard touchdown catch for San Diego (3-1).Passing because the Chargers’ running game is nonexistent due to injuries to Ryan Mathews and Danny Woodhead, Rivers had his second three-touchdown game of the season.

Colts 41, Titans 17At Indianapolis, Andrew Luck threw four touchdown passes and Reggie Wayne scored for the first time this season. Indianapolis (2-2) extended its league-leading streak of consecutive wins over division foes to nine.Luck was 29 of 41 for a season-best 393 yards. Wayne had seven catches for a season-best 119 yards and scored on a spectacular spinning 28-yard catch.

Vikings 41, Falcons 28At Minneapolis, rookie Teddy Bridgewater passed for 317 yards and a key 2-point conversion before leaving with a left ankle injury. He was 19 for 30 with no turnovers and ran five times for 27 yards and a score in his first career start.Matt Asiata had three touchdowns on the ground for Minnesota (2-2).

Dolphins 38, Raiders 14At London’s Wembley Stadium, Ryan Tannehill threw for 278 yards and two touchdowns in the latest international game. Tannehill took advantage of a depleted Oakland defense to snap a two-game slide for the Dolphins (2-2).The Raiders (0-4) scored on their opening drive but struggled after that. And starting quarterback Derek Carr was injured in the third quarter, replaced by third-stringer Matt McGloin.

Lions 24, Jets 17At East Rutherford, New Jersey, Matthew Stafford threw two touchdown passes and ran for another score as the Lions overcame Calvin Johnson being limited by an ankle injury.Jeremy Ross and Eric Ebron caught scoring passes for the Lions (3-1), and Stafford passed for 293 yards. Golden Tate had a big game, catching eight passes for 116 yards.

Texans 23, Bills 17At Houston, J.J. Watt turned the game with a highlight-reel play. Houston (3-1) was down by three in the third quarter and Ryan Fitzpatrick had just thrown a second interception when the 6-foot-5, 289-pound Watt returned an interception 80 yards to put the Texans up 14-10.