Pittsburgh Pirates' Bryan Reynolds smiles after his two-run home run against the Cincinnati Reds during the first inning of a baseball game Tuesday, June 25, 2024, in Cincinnati. Associated Press

CINCINNATI — Bryan Reynolds extended the longest active hitting streak in the major leagues to 22 games with a two-run home run in the first inning, and the Pittsburgh Pirates beat the Cincinnati Reds 9-5 Tuesday night.

Reynolds’ streak is the longest by a Pirate since 2003 when Kenny Lofton hit safely in 26 straight games. Jason Kendall and Aramis Ramirez had 23- and 22-game streaks, respectively.

It was a rough start for the Reds' Hunter Greene, who was evaluated by training staff after throwing up on the mound in the first inning following a six-pitch walk to leadoff batter Andrew McCutchen.

Reynolds followed with his home run on a 3-2 pitch to put the Pirates ahead 2-0.

Greene (5-3) worked through a three-run, 32-pitch first inning and managed to last four innings, allowing six earned runs on seven hits with two walks and five strikeouts.

The Pirates hit five straight singles to begin a three-run third inning, increasing their lead to 6-0.

Jared Triolo's two-run home run off Buck Farmer made the score 8-0 in the fifth.

Pittsburgh's Mitch Keller (9-4) allowed three earned runs on six hits in 5 2/3 innings, extending his streak of pitching at least five innings to 47 straight games.

It's the longest such streak since the Braves' Max Fried went 50 straight starts from June 6, 2021 to Sept. 30, 2022. It’s the longest by a Pirate since A.J. Burnett went 49 straight starts from May 8, 2012 to Aug. 10, 2013.

Pirates: LHP Ryan Borucki (right triceps inflammation) began a rehab assignment Tuesday night with Triple-A Indianapolis.

The Pirates and Reds conclude their three-game series Wednesday afternoon. Neither team had named their starting pitcher.