The flurry of federal investigative activity last week — with feds seizing the electronics of five of the mayor’s most senior officials — sent tremors through City Hall, raising questions about how they would affect Mayor Eric Adams’ ability to govern effectively and offering new fodder for a growing roster of opponents as he heads into a mayoral election.

Adams was already plagued by sharp challenges, including a rift between him and the City Council, low approval ratings and hungry political challengers. A federal investigation into ties between his 2021 campaign and Turkey has been looming over the administration for months. The mayor is facing a lawsuit accusing him of sexual misconduct, which he denies.

The new investigations — which have ensnared some of his closest allies — add a complex and potentially troubling layer to the puzzle. Details of the investigations have not been disclosed, but sources say the feds are scrutinizing in the role of the brothers of two powerful city officials who may have abused their family connections for their own benefit.

Terence Banks, a former MTA official-turned-consultant and the brother of Schools Chancellor David Banks and Deputy Mayor for Public Safety Phil Banks, is being investigated for possibly leveraging his brothers to secure city contracts for his clients. James Caban, the twin brother of former NYPD Commissioner Edward Caban, is separately being looked at for hawking his access to the top cop to bars and nightclubs.

The probes have already had fallout. In response to the scrutiny, Edward Caban stepped down from his role, saying he didn’t want to become a “distraction” for the administration. A City Hall staffer was fired after a televised report connected him to James Caban.

No one has been accused of wrongdoing in the probes, and Adams has stuck to his key talking points amid the swirl of questions: He follows the law and has told his people to do the same. He routinely points to progress his administration has made on issues like reducing crime, critical to many New Yorkers.

Basil Smikle, a political strategist and former head of the state Democratic Party, agreed that right now, “It’s business as usual at City Hall.”

But he said the events of the past week could stir public doubt about Adams’ leadership.

“Up until this point they could argue that this was just a distraction, the city keeps moving forward,” he said of the administration. “But when the commissioner resigned, that’s more serious, because that means the highest law enforcement officer in the city could not continue to do his job.”

The situation was further complicated late Saturday when the mayor’s chief counsel, Lisa Zornberg, announced she was stepping down.

Political opponents of the mayor have seized on the disruption amid questions of whether the focus on the investigations will distract from critical efforts, such as NYPD recruitment and attrition.

“Under Eric Adams, New Yorkers have been subjected to just an endless stream of chaos,” Ana María Archila, co-director of the New York Working Families Party told the New York Daily News, referencing the recent raids as well as budget cuts and other issues. “I think the combination of both his endless string of scandals and his chronic management of the city makes it hard for New Yorkers to know that their government will deliver. It’s distracting to not only the mayor but his entire team.”

State Sen. Jessica Ramos formally announced she was challenging Adams for the Democratic mayoral nomination on Friday, at the end of a long, tumultuous week for the current administration.

Other challengers are circling, eager to seize on a prime opportunity to slam that mayor’s governance.

In response to Caban’s resignation, mayoral candidate Scott Stringer slammed the Adams administration as “rudderless and chaotic”; State Sen. Zellnor Myrie wrote that the step-down was part of a “concerning pattern of instability”; and city Comptroller Brad Lander called for a “series of real management reforms and public integrity safeguards.”

But other insiders and political strategists see the current situation differently, arguing New Yorkers will judge Adams based on how the city is being run when it comes to issues that directly touch their lives.

Rodneyse Bichotte Hermelyn, a strong ally of Adams, said she has full confidence in the mayor and his administration and that the investigation would not have any impact on their governance.

“There’s something called bureaucracy. The city continues to move on regardless of who’s in the leadership role and that’s because there are structures in place to do so. Executives can come and go and leave but the city is still moving,” she told the Daily News, citing Gov. Cuomo’s resignation in 2021 as an example.

Bichotte Hermelyn, who also leads the Brooklyn Democratic Party, said the recent events won’t hurt Adams’ electability, calling the investigation at this point “insider politics.”

“People are more concerned about the basic things like shelter, education, safety and things of that nature,” she said. “Mayor Adams, despite of what would be considered a lot of distractions, he’s still running the city.”