WASHINGTON — Presumptive Republican presidential nominee Donald Trump’s derision of his political opponents draws hearty boos of support at rallies. That he castigates as many Republicans as Democrats is another sign of the fractures within the GOP.

Trump shrugs off the high-profile Republicans who have stated they aren’t voting for him, among them former Florida Gov. Jeb Bush and Sen. Lindsey Graham, R-S.C., both one-time rivals for the nomination he has all but won. While Trump declares that such GOP naysayers don’t really matter when compared to all the votes he garnered in primary elections, he still takes time to mock Bush and Graham.

Appearing at rallies Friday in Nebraska and then Oregon, Trump repeated his nickname for Democratic front-runner Hillary Clinton — “crooked Hillary” — but stepped up his attacks on Clinton by referencing her husband’s infidelities for the first time since he became his party’s presumptive nominee while dismissing her criticism of how he treated women.

“Bill Clinton was the worst in history and I have to listen to her talking about it?” Trump said. “Just remember this: She was an unbelievably nasty, mean enabler. And what she did to a lot of those women is disgraceful. So put that in her bonnet and let’s see what happens.”

Trump also turned to a relatively fresh target, Sen. Elizabeth Warren. The Massachusetts Democrat, he said, is a “goofus” and a “basket case” who has done nothing in the Senate. Warren, a favorite of the Democratic left whom some would like to see as Clinton’s running mate, had insulted Trump earlier on Twitter, calling him “a bully who has a single play in his playbook.”